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CST: 19/10/2019 15:03:30   

Amydis Awarded NIH Ph2A Grant for Cerebral Amyloid Angiopathy

26 Days ago

SAN DIEGO, Sept. 23, 2019 (GLOBE NEWSWIRE) -- Amydis, Inc., a privately-held pharmaceutical company developing proprietary drugs to detect, monitor, and screen for amyloid-related diseases, announced today that they received a Phase 2A SBIR grant award from the National Institute on Aging of the National Institutes of Health (NIH). The grant award for over $1,500,000 will continue to fund the development of a novel ophthalmic diagnostic compound for Cerebral Amyloid Angiopathy (CAA), an age-associated disease in which proteins called amyloid build up on the walls of the arteries in the brain increasing the risk for stroke caused by bleeding, and dementia.

CAA is a major cause of spontaneous intracerebral hemorrhage in people older than 55 and an important contributor to age-related cognitive decline. Physicians are unable to diagnosis CAA with certainty without a sample of brain tissue. Current diagnosis of CAA involves expensive imaging tests such as MRI, CT scans, and PET amyloid tests.  The Amydis technology is envisioned to provide an affordable and accessible retinal imaging test as a welcome addition to the armamentarium of tools available to physicians.

“We are honored that the NIH has again selected Amydis for continual support. It will allow us to accelerate the development of our lead compound toward clinical trials,” stated Stella Sarraf, Ph.D., Chief Executive Officer and Founder of Amydis, Inc. “We hope our test will serve as an outcome marker in clinical trials and catalyze the development of potential therapeutics that can stop or reverse progression of the disease. We ultimately envision it becoming widely used as a simple and low-cost screening test.” 

Steven M. Greenberg M.D., Ph.D., Professor of Neurology at Harvard Medical School & Director of the Hemorrhagic Stroke Research Program at Massachusetts General Hospital and a leading CAA authority who is unaffiliated with Amydis said, “I am excited the NIH is continuing to support Amydis. I am keenly aware of the challenges CAA patients face in the diagnosis and treatment of disease.  I believe that diagnosis of CAA through the eye would be a tremendous step forward for the field and I believe the CAA community will be eager to help the Amydis team pursue their vision of a novel diagnostic probe.”

About Amydis, Inc.
Amydis, Inc., founded in 2013, is a privately-held company discovering novel small molecule drugs to allow direct visualization of CNS molecular pathology through the retina to detect, monitor, and screen diseases that involve the presence of amyloid proteins.  Our mission is to develop a simple, non-invasive eye test that is faster, more accessible, and more affordable than current tests. Amydis has a platform of novel compounds that fluoresce when bound to amyloid-related proteins, thus enabling visual diagnosis of such diseases. Amydis pharmacologic compounds will enable eye care specialists the ability to refer patients at risk early to neurologists, addressing a current unmet need and gap in our healthcare system where patients see a neurologist when the disease is advanced. Neurologist will have access to the first affordable and accessible tool to quantifiably monitor disease progression. The Company’s most advanced programs target early detection of Parkinson’s Disease and Alzheimer’s Disease. Other development programs include the detection of Cerebral Amyloid Angiopathy, Creutzfeldt-Jakob disease, and Traumatic Brain Injury, all of which are associated with the presence of amyloid proteins. For more information on Amydis, please visit http://amydis.com/.

Disclosure

Research reported in this grant publication is supported by the National Institute On Aging of the National Institutes of Health under Award Number R43AG058350 & R44 AG058350-02. The content is solely the responsibility of the Company and Principal Investigators and does not necessarily represent the official views of the National Institutes of Health.

Amydis Contact:

Stella Sarraf, Ph.D.
Chief Executive Officer, Founder
stella@amydis.com
310-229-5710

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